Based on the Coast Guard Historian’s timeline, https://www.history.uscg.mil/research/chronology/
With inspiration from Mike Kelso

United States Revenue-Marine revenue cutter USRC Wolcott (1873) at her home port, Port Townsend, Washington.

1886 USRC Wolcott made the Revenue Marine’s first drug seizure when a landing party seized 3,011 1/2 pounds of opium hidden at the Kaasan Bay Salmon Fishery, in Alaska.  A detail of officers and crew from the Cutter had previously assisted Customs Inspectors with the seizure of 695 pounds of opium from vessel Idaho in Port Townsend.  When a disgruntled crewman later provided intelligence about the additional opium stored at Kaasan Bay, RC Wolcott’s crew ensued on a 695-mile race to beat Idaho to the concealed drugs, resulting in the RMS’s first and largest-ever opium seizure. Hot on the Opium Smugglers’ Trail | Naval History Magazine – October 2016 Volume 30, Number 5 (usni.org)

Coast Guard Hall PH-3 loading depth charges

1942  A Coast Guard aircraft, Hall PH-3 No. V-177, dropped food to a raft with six survivors of a torpedoed tanker in one of hundreds of such incidents carried out by Coast Guard aircraft during the war.  This tanker had been the victim of a German U-boat attack off the coast of the United States.

1985  Vice President George Bush made an official visit to Base Miami Beach to extend the thanks of the nation to those involved in Operation Hat Trick, an “all-out” effort to stop smugglers soon after they had left ports in Central and South America.  The vice president decorated 15 Coast Guardsmen.

U.S. Coast Guard Cutter THETIS (WMEC-910) , US Navy photo ID:J3103SPT95001725 / DNST9800595

2004  CGC Thetis rescued three shrimp fishermen from the fishing vessel Dona Nelly after they were in the water for 45 minutes after their vessel sank 15 miles off the coast of Brownsville, Texas.