The VAMPIRE system can fit in almost any pickup or vehicle with a cargo bed. (Courtesy of L3Harris)
Earlier I said I would talk about some of the weapons I thought would be most appropriate for cutters, particularly the Webber class WPCs, that would allow them to respond to range of threats including:
- Unmanned aircraft, from the smallest to converted light planes
- Small, fast, highly maneuverable surface craft including personal watercraft
- Merchant ships of any size
The APKWS is the first and it has proven particularly useful against drones and should be similarly effective against small watercraft and small ships. Its ability to forcibly stop or sink medium or large ships is limited, but I would say the same about the 57mm. Reportedly systems hurriedly shipped to Ukraine have shot down hundreds of drones and now APKWS are being made in very large numbers. For a guided munition, costs are very low, $15K to 20K for the guidance section and a few thousand for the very old tech 70mm Hydra rockets.
I could see the four round launchers mounted where the .50 calibers are mounted forward of the bridge on the O-1 deck, on the Webber class WPCs.
The basic APKWS requires full time laser designation from launch to impact. The system is evolving. An infrared seeker has been developed. This would allow the user to more rapidly shift from one target to the next.
The Launcher and fire control system commonly associated with surface launched APKWS is the L3Harris VAMPIRE. The US Naval Institute assures us that a naval variant is being developed and The War Zone shows us how ubiquitous this system is becoming and how it might develop.
Chuck Hill's CG Blog 
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The Mk66 Hydra Rocket should be upgraded with the new energetics (rocket fuel/warheads) that have been developed since the last upgrade. Those volumes (Mk66 rocket tube/warhead volume/shape) can be so much more capable, and it will only take a little development.
There are rocket motor manufacturers that 3D print the fuel in the rocket tube. I would suggest the same could happen with the warhead on an assembly line.
This development would support every armed service using Hydra Rocket Launchers which are already built to a standard/form factor.
In the mean time the actual Hydra Rocket System can be installed in/on multiple platforms and the feedback of upgrades begin on those platforms.
Just my 2ȼ.
I noticed that l3/Harris has address one of the limitations of the vampire by placing 3 modules together making the load out 12 apkws. Two of these on a Weber would be harder to overwhelm with numbers, making it even more useful.
Of course larger cutters could use the h-60 to carry the apkws.
In an ideal world, I would prefer the USCG cutters, and perhaps even the LCSs to have the Sierra Nevada Corporation’s BRAWLR missile launch pedestal unveiled at AUSA 2025. With 23-rounds of APKWS II and multiple missile rails for AIM-9 and AIM-120 (NASAM) missiles, the BRAWLR adds multiple launch options for ONE pedestal. It can attack and defend with its mounted armaments and even though it might have just one missile of that type mounted, it’s the most firepower for its compact size and surely enough for NSCs and OPCs that rarely if ever fire a shot in anger.
https://defence-blog.com/snc-unveils-modular-air-defense-launcher-at-ausa/