Interim Maneuver Short-Range Air Defense (IM-SHORAD). The sensors and remote weapon system used here looks like it might be a contender.

The Navy is looking for mature counter Unmanned Air Systems (c-UAS) that can be rapidly deployed. They have issued a Request For Information (FRI). Responses are due today, so we are talking near term if it happens. 

Looks like it might be something the Coast Guard could use,

Marine Air Defense Remote Weapon Station. Use of this Remote Weapons Station would require an interface with cueing sensors.

Below is SECTION 3: [Requirements Overview]

PEO IWS 11.0 is looking for respondents to submit feasibility and capability information on innovative, mature solutions to counter Group 3-5 UAS from surface ships.  System requirements include:

1. Mature systems that are in production and can be deployed in 1-6 months (preferred), or 6-12 months at the latest.
2. Demonstrated performance against Groups 3 to 5 UAS, with demonstrated capability against other classes of UAS’s being of interest.
3. Minimal integration requirements with Naval combat systems; with independent, self-contained capability highly desirable.

If the system is capable against Group 5 UAS (the largest UASs, over 1320 pounds (600 kg) and with no limit on their maximum speed) it’s likely the system will also have a capability against at least subsonic cruise missiles and manned aircraft and perhaps against winged smart bombs. After all, a Naval Strike missile fits the definition of a Group 4 UAS. Surface launched Harpoon or Tomahawk would be Group 5 UAS.

The War Zone has a fairly long post about this including discussion of alternatives. They seem to think these systems are destined for DDGs, but I think the need to equip other types, that do not have robust AAW capabilities, may be more urgent. If a C-UAS has an anti-surface capability, I could see such a system replacing Mk38 mounts. Alternately a 30mm Mk38 Mod4 mount that also mounts AAW missiles (like Stinger) might meet the requirement.

Martlet Light Multirole Missile launchers mounted on MSI 30mm gun mount that will be used in US Navy service as the 30mm Mk38 Mod4.

Mine Countermeasures Ships and MSC ships are currently essentially unarmed. They might be recipients.

“Minimal integration requirements with Naval combat systems; with independent, self-contained capability highly desirable” would certainly mean it should not be too difficult to add to a cutter.